热门靶点Cadherin-17重组蛋白钙粘蛋白17

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热门靶点Cadherin-17重组蛋白钙粘蛋白17

Cadherin-17信息

英文名称：Cadherin-17
中文名称：钙粘蛋白17
靶点别称：Liver-intestine cadherin，HPT-1，CDH16，Intestinal peptide-associated transporter HPT-1，LI-cadherin，HPT-1 Cadherin，Cadherin 17， LI Cadherin (Liver-Intestine)，HPT1，Human Intestinal Peptide-Associated Transporter HPT-1，LI Cadherin，Cadherin，Cadherin 17，Human Peptide Transporter 1，Cadherin-16
上市药物数量：0
临床药物数量：2
高研发阶段：临床一期

Cadherin-17分子背景
Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

表达区间及表达系统（Source）
Biotinylated Human Cadherin-17, His,Avitag (CA7-H52E6) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Met 787 (Accession # Q12864-1 ).
Predicted N-terminus: Gln 23

蛋白结构（Molecular Characterization）
Cadherin-17 Structure
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™)
The protein has a calculated MW of 88.6 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

标记（Labeling）
Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

蛋白标记度（Protein Ratio）
Passed as determined by the HABA assay / binding ELISA.

内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.

纯度（Purity）
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.

制剂（Formulation）
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.
Contact us for customized product form or formulation.

重构方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

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